Below is a really interesting technological packaging advancement that is truly exciting and could have major benefits in the healthcare and pharma packaging & clinical trials sectors. Design Cognition also believe that this technology has further application in other dosage forms and sectors and is working with DSM TCG & GP Solutions (UK) Ltd to develop the OtCM™ and Dose Guard™ technologies in innovative ways to meet the demands of end-users and industry and bring this product to market in a viable & cost-effective manner.

Please contact me (chris@designcognition.com) if you’d like more information or come and visit us at Packaging Innovations at the NEC, Birmingham UK on 24th or 25th Feb (stand 582), where we can discuss in more detail. You can register HERE.  Chris Penfold

When was the last time you forgot to take your medication? Odds are that it was within the last week. This makes you part of the millions of patients who don’t take their medications as prescribed by their physician. Medication non-adherence, or mal-compliance, as it is commonly called, is a problem that disrupts the healthcare system in many ways. If you don’t take your medication odds are that you won’t get the full benefit of the treatment. As former US surgeon general Dr. C. Everett Koop said, “Drugs don’t work in people who don’t take them”. In the worst case, you could be among the patient population who are hospitalized as a result medication non-adherence. The cost to the healthcare system? Phenomenal! Mortality count? Sinister! Morbidity rates? Unacceptable!

At its root, this problem, like many, is a problem of human behaviour. Even Hippocrates (460-377 BC), the “Godfather of Medicine”, gave early warnings of the non-compliance issues to his students and colleagues. (”Keep watch for that fault in patients which makes them lie about the taking of things prescribed.”). Even though we are “creatures of habit”, we often lose momentum when taking medications, especially for chronic conditions.

The Non-Compliance Money Waste List

There have been several attempts at using technology to influence compliance rates. As one scans the Web looking for potential help, some solutions that arise include:   (1) A variety of medication reminders that will beep, blip or blurt when it is time to take your medication. (2) A variety of devices that can track the number of times a medication dosage has been removed from a medication pack or a medication container (USA) that has been opened. The data collected can be downloaded at the doctor’s office or pharmacy to check compliance statistics. (3) A variety of devices that can remind the patient to take their medications and confirm that they have taken it by pressing a button to send the data.  (4) A miscellaneous group of reminder devices with alarms, like automated pill boxes or wrist watches.

OtCM™ -  Objective therapy Compliance Measurement.

One of the weaknesses of these approaches is that one can never guarantee that the patients have taken their medicine after an alarm. In fact, one can’t detect if the medication unit dosage has been taken, or if the medication unit dosage has even been taken at the right time.

A new technology has arrived that has the potential to dramatically impact the therapy compliance rates for individuals, particularly seniors, as they go about their daily lives. The name of this technology is OtCM™, Objective therapy Compliance Measurement, using the most recent RFID/NFC (Radio Frequency Identification, Near Field Communication) technology, including embedded sensor functionalities, and combined with printed organic electronics.  The OtCM™ application was invented by Jos Geboers and Willem Kort, who are working in the healthcare industry, especially in clinical pharmaceutical R&D, Health Economics, Outcomes Research and Patient Recorded Outcomes.  To that purpose Messrs. Geboers and Kort initiated the foundation of a consortium that includes all players, i.e. top listed pharmaceutical companies, medication packagers, health insurers and Royal DSM N.V.: “The Compliers Group” (DSM TCG).  DSM TCG wanted a way to be as certain as possible that patients were taking their medications at the correct frequency each day. They knew that, whatever solution they decided on, it needed to be “real time” since any delays in therapy could have serious health consequences. A novel system for measuring the time and quantity of drugs taken out of conventional, existing medication packaging or medication container, is used.  “Leading” versus “Bleeding” edge …

The existing medication package will do …

The system consists of conventional, existing medication blister pack (or “bottle”) of a given prescription drug furnished with “organic electronics” (circuitry, power supply), i.e. functional polymers and coatings, to print “the micromechatronic blister/bottle”. A “traditional” silicon RFID/NFC IC (Integrated Circuit) that has been especially designed for OtCM™ with integrated interfaces for i.e. clock and temperature functionality, provide the intelligence to identify data (date-time) of pills/capsules that have been taken out of the blister pack/bottle, whilst wireless Radio Frequency (RF) techniques (NFC, Near Field Communication) are able to transfer data wirelessly from the “OtCM™ enabled blister/bottle” onto DSM TCG’s webserver.

Driven by the intelligence of the RFID chip, embedded in the “mechatronic circuitry”, and the printed power supply (capacitator, battery), an electric current is circulating through the circuitry of the packaging at regular time intervals. As soon as a dosage is removed out of the packaging, the chip is activated. This information is stored. When in close proximity of a (NFC) reader,  the recorded information in the packaging will be transferred and stored in the server to populate the Therapy Compliance Database of active patients, under all regulatory recommended & required security and privacy conditions, locally and globally.

The standard existing medication blister package will do at a fraction of the traditional costs!

The concept of using the technology of printing functional polymers and coatings is an innovative approach. A large variety of  applications in real-life situations has been brought about, especially for purposes of identification of products and, consequently, the packaging of products.  The standard medication blister package will do at a fraction of the traditional costs!   Moreover, until now, traditionally available therapy compliance devices are extremely costly, even if mass-produced. Mass produced RFID-tags combined with polymer printing will introduce low-pricing schedules, based on factors of 90-95% reduction vs. currently available “traditional electronic” OCM devices, i.e. pill boxes or so-called “smart pill boxes”.

DSM TCG’s OtCM™ technology can be combined with GP Solutions (UK) Ltd’s patented and approved Dose Guard™ solution; a child resistant senior friendly secondary barrier that when applied to a blister pack will render it safe for use. Both “come with the standard, existing medication package”.  From surveys it has been identified that patients and health practitioners (physicians, medical specialists, pharmacists) only appreciate the enabling of OtCM™ right from the medication packaging. There obviously is no need for an additional, “stand-alone” therapy compliance measurement (recording) device separated from the medication package.

During OtCM™ we measure through the standard medication packaging:

(1) when the pill/capsule is taken,

(2) the location of the removed pill/capsule onto the blister packaging,

(3) the correct dosing schedule,

(4) an acoustic signal might prompt the for action,  data re: expiration date,

(5) production information re: temperature, batch IDs from the production line,  drug interaction alerts.

This real-time “interventional approach” is what stands apart from other compliance solutions.  In conclusion, it is clear that there are several technological approaches that are aimed squarely at the problem of medication compliance. Though these advances give our “inner geek” some encouragement, they are ultimately targeted at making sure that at-risk populations stay on track as they take medications to improve their health status. David Rosa, Willem Kort

You can find further information on compliance and evolving technologies, via Design Cognition’s sister site ‘The Pharma Gateway‘. Also, if you are interested in our forthcoming compliance workshops – let us know.

Contact Chris Penfold (chris@designcognition.com).

As 2009 draws to a close, we’d like to express our thanks and best wishes to all of our customers, suppliers and associates. Have a fantastic Christmas break and a happy & prosperous New Year and we look forward to doing further business with you all in 2010.

The Design Cognition team have put together the attached video production as a bit of light hearted seasonal frivolity.

We hope that you like it.

A researcher at Massachusetts Institute of Technology (MIT) who used to be a brand manager at luxury goods firm Louis Vuitton Moët Hennessy (LVMH) asked hundreds of fake bag buyers about their habits in an unpublished study ‘The Real Value Of Fakes’.

Renee Richardson Gosline interviewed the consumers who knew when they bought them that the bags were fakes and found that 46% of them bought authentic branded bags within two years.

“For some status-seeking people, at least, the social power of luxury goods means that consumption must not just be conspicuous, but real,” said a statement from MIT describing the research.

“The counterfeit actually served as a placebo for brand attachment,” Gosline told news service Bloomberg . “People were becoming increasingly attached to the real brand even though they never possessed it at all.”

You can read the full article here: OUT-LAW New

You can find further information on counterfeiting and evolving technologies, via Design Cognition’s sister site ‘The Pharma Gateway‘. Also, if you are interested in our forthcoming counterfeiting workshops – let us know.

The dangers of counterfeiting drive the need for package and brand security. The following is an extract from a recent Converting Magazine event in the US, detailed by Natalie Hasselbacher, Converting Magazine, 3rd June 2009, which provides some useful insights into successful anti-counterfeiting and security techniques and technologies.

Three speakers presented during an anti-counterfeiting session on the importance of product security and possible ways for its implementation among capable converting facilities. Discussions highlighted a desperate need for package security to save a company’s brand whilst also ensuring safety to consumers.

Jim Reiman, Sales Director at Sun Chemical Security, said once anti-counterfeiting technology is applied to a package or label, the most important thing for brand owners to consider is a strategy and who will authenticate. “Articulating a high-level strategy and defining the problem is important,” he said. “Clearly articulating requirements with metrics and an internal agreement among company employees for proper implementation is a must. You have to question whether consumers, customs, investigators or retail will authenticate.”

Reiman also discussed Sun Chemical’s newest technologies that reportedly fight counterfeiting. The Verigard is a low level taggant that is said to work in any ink or adhesive while printing using most methods including flexo, gravure and offset.

A second speaker, Jim Colby, a Consultant for ExPev Solutions, referred to interdiction, authentication and a secure supply chain as the three ways to stop counterfeiting.

Thirdly, Juliet Midlik, Sales Manager for Prime UV Systems, mentioned that most of the company’s customers purchasing UV drying systems are applying anti-counterfeiting coatings and inks on food packaging.

The full article can be read here: http://tinyurl.com/yaq3nf4

You can find further information on counterfeiting and evolving technologies, via Design Cognition’s sister site ‘The Pharma Gateway‘. Also, if you are interested in our forthcoming counterfeiting workshops – let us know.

Just a quick note to confirm that both Annie and myself have been honoured with the title of Chartered Environmentalist (CEnv) by the Society for the Environment, through our membership of the Institute of Materials, Minerals & Mining (IOM3) and because of our life-long commitment to developing sustainable packaging solutions in our day-to-day projects. It’s nice to have it recognised and, by implication, recognition of the fact that packaging actually provides a beneficial (environmental) role in society.

This also sits nicely with our appointment last year as Technical Advisors to WRAP (the UK government-run Waste Resources & Action Programme) in ‘Waste Minimisation – Packaging Product Waste’. I feel that a key component of this has been our understanding of the requirements of present environmental legislation, in particular the Producer Responsibility Obligations (Packaging waste) and Packaging (Essential Requirements) Regulations, which have been key in a number of recent environmental & sustainability assessments

‘Sustainable development’ to me is all about taking a ‘helicopter’ view of any product development to understand:

• environmental impacts throughout the whole supply chain (from raw material extraction, through use & disposal, to reuse and recovery) whilst
• attempting to meet consumer convenience needs,
• BUT minimising the overall environmental impact through intelligent design of pack (primary, secondary & tertiary), using the optimum material specifications & most economical footprint possible.

I believe that key to our CEnv award was our continued application of the principles of sustainable environmental management and development in our work. Over my 30 year career ‘the environment’ has become ever-more prominent on everybody’s agenda, evolving from the early days of the ‘Topfer Decree’ to the more recent ‘Plan A’. We have endeavoured throughout to apply the principles of sustainable environmental management and development in all of our work as ‘environmental packaging champions’:

• Acting as an internal consultants for marketers & other business stakeholders – advising on ‘fitness for purpose’ and ‘environmental best-practice’.
• Highlighting issues with existing packaging to our work colleagues
• Applying ‘sustainable principles in the hundreds of packaging developments on which We’ve worked

Moving forwards, I pledge that Design Cognition will continue applying the principles of sustainable development and environmental responsibility in all of our work. As CEO of a company that not only develops packaging but also acts in a consultancy capacity (advising on packaging ‘sustainability’ & ‘the environment’) I carry the mantle with a great deal of pride and self-fulfilment – enjoying making a ‘real difference’ in the world.

• Our initial discussions with clients always encompass sustainable aspects – and that will continue
• One of our ‘values’ (shown on our website) is to be ‘environmentally aware’:
• “bearing in mind our impact on the environment and eco-systems in all that we develop and in our day-to-day business”
• Through this ethos I will encourage all in Design Cognition to ‘live’ our environmental policy as a holistic approach to encompass not only work we do for clients but also in our day-to-day business activities.

We look forward to working with you

Chris

I found the following article via a LinkedIn packaging group and it gives an interesting overview of size, trends, obstacles, opportunities and predictions pharma packaging industry. Have a read of the full article and let us know what you think. Chris

According to a survey conducted by Pharmaceutical Technology Europe (PTE), almost 50% of you believe that cost is the biggest limiting factor to innovation in the pharmaceutical packaging industry, while regulations were also thought to present a major hurdle to new development, accounting for almost two-thirds of the remaining votes.¹ The pharmaceutical industry recognizes the importance of good packaging design, in particular because of the continuing pressure to aid patient compliance, meet regulatory demands, and increase a brand’s life and appeal; however, manufacturers must also innovate while improving efficiency and adapting to the growing threat of drug counterfeiting.

You can read the full article here (but may need a LinkedIn account):

http://fb.me/3mDlBhX

Via LinkedIn link to Pharmaceutical Technology Europe, Volume 21, Issue 11 Nov 1, 2009
Article by: Fedra Pavlou, Stephanie Sutton, Corrine Lawrence

It has been mandatory since 2005 in the European Union to include Braille text on the pack of every newly approved medicine, including uncontracted forms of the drug name and its strength if more than one is made available. By 30 October 2010 the requirement will be applied to all products, regardless of when they were approved.

Annie Dallison – CTO at Design Cognition

Indeed our Chief Technical Officer Annie Dallison has been at the ‘cutting edge’ of this legislation for a number of years as a member of The European Committee for Standardization (CEN) working group on Braille standards. Annie, as a leading industry expert, already had over 8 years of experience in the application of Braille on pharmaceutical packaging developing processes and establishing & setting standards for blue chip companies, making her an ideal member of the working group.

CEN working group

The CEN working group is made up of dedicated representatives from the packaging industry, trade associations, regulatory bodies and blind associations from across Europe. The group has been working for over 3 years to determine and agree standards, including the Braille font style and measurement of Braille cell dot height that can be applied across the whole of the EU.

The following article provides an interesting insight, from a packaging supplier’s perspective, into the implementation of the imminent Braille legislation. Craig Jasper, Director of Sales for the paperboard converting equipment at Roberts PolyPro, a division of Pro Mach, discusses the obstacles facing Braille embossing on pharmaceutical packages.

Craig Jasper – Director of Sales at Roberts PolyPro

In the article Jasper confirms that “It is a very noble cause. Yes, the number of blind people is less than 2% — and older people that become blind late in life cannot read Braille — but, try to imagine an elevator or an ATM without Braille. It has become part of the fabric of our lives in so many places and it is the right thing to do for those that need some assistance in everyday functions. Also coming up next year it is the 200th birthday anniversary of Louis Braille.” He goes on to talk about obstacles that pharmaceutical companies face with regards to incorporating Braille embossing on packages, and how he feels that the regulation will encourage countries outside of the EU (South America are expecting it to happen there very soon!) to adopt a similar mandate regarding Braille embossing.

You can access a FREE Braille factsheet at The Pharma Gateway HERE

You can read the full PharmaTech article here: http://bit.ly/611BQv (Via Pharmaceutical Technology Europe, Nov 1, 2009)

Interesting article and data  on the importance of continued investment into innovative packaging and graphics (Annie)

Year long survey consistently finds that structure might best communicate innovation, especially with supportive graphics. Materials and production also are good barometers. In any economic environment, innovation is key to growth. But, during a recession, many companies are tempted to reduce spending on innovation to save money. Luckily, this is not an absolute rule. Daring brands still pushed the boundaries of packaging innovation in 2009.Earlier this year, Shelf Impact! and international brand consultancy Dragon Rouge formed a partnership to ask branding and packaging professionals to evaluate recent product and packaging innovations. Each quarter, we asked a sample of hundreds of Shelf Impact! readers, from brand managers to designers to materials suppliers, to rate a selection of packages on matters of innovation. View an image and brief description of each of the 10 packages reviewed this quarter.

via Shelf Impact: “Achieving attention-getting innovation” Filed In:.

Despite the current economic climate manufacturers are still pushing forward with making their products more sustainable.  More sustainable doesn’t have to mean more expensive and I think that’s the key to this – it might appear all very ‘trendy’ at the moment to talk about sustainability, but in the long run it can help to cut your costs and more importantly help your profits. (Jane)

Most grocery manufacturers have either maintained or increased their investment in sustainability during the recession a survey has found, indicating the importance it will play for businesses in the coming decade.

via Sustainability no less important in recession, survey.